Intranet
Staff

Martina Scichilone

Dottorando
Application Areas
Research Areas
Research Lines
Projects
E-Mail

martinascichilone@cnr.it

PHONE

none

LOCATION

Segrate

ROOM (floor/number)

6/20

I am a PhD student working at Tommaso Selmi’s lab and collaborate with Cinzia Cocola, PhD and Paride Pelucchi, PhD, on CRISPR-based screenings using cytosine base editing and Cas9 knock-out approaches in cancer cell lines. We are currently applying CRISPR screens to study the role of RNA-modification pathway effectors in cancer proliferation and drug resistance. I am also collaborating with the Pharmacogenomics group led by Francesca Colombo, PhD.

Development of high-throughput CRISPR screening platforms, integrating machine learning-guided library design with large-scale genetic perturbation experiments in different biological contexts

Characterization of the functional landscape of single nucleotide variants (SNV) in disease models by using large-scale CRISPR screens and quantifying variant effects via phenotypic and transcriptional readouts

Regulation of gene expression by transient or constitutive modulation of genes to provide insights into gene function and therapeutic potential in disease models

Determination of how Single Nucleotide Variants (SNVs) in RNA-modification effectors influence cancer cell proliferation and drug resistance

Study of the role of tRNA modifications and tRNA-derived fragments in regulating translation to control stem cell self-renewal and differentiation

Investigation of how specific RNA modifications and ribosome translation dynamics together influence stem and cancer cell proliferation and fate decisions