Omics and Related Technologies
RESEARCH AREA
research line
Epitranscriptomics
The epitranscriptome identifies a group of more than 100 RNA chemical modifications that dynamically govern a cell’s translational output at transcriptional and post-transcriptional level. At ITB, we integrate cellular, biochemical, molecular, and sequencing approaches to map RNA modifications on the transcriptome of mammalian cells and define their impact on gene expression.
Research Activities
Study of the role of tRNA modifications and tRNA-derived fragments in regulating translation to control stem cell self-renewal and differentiation
Investigation of how specific RNA modifications and ribosome translation dynamics together influence stem and cancer cell proliferation and fate decisions
Determination of how Single Nucleotide Variants (SNVs) in RNA-modification effectors influence cancer cell proliferation and drug resistance
