MATITE

MATITE is an interdisciplinary project aimed at defining the biology underlying the expression, regulation, and function of repetitive elements (RE) in the genome through an innovative combination of multi‑omic and biological methods. The functional genomic approach begins with a comprehensive bioinformatic analysis of available omics data, developing an optimized computational pipeline for RE mapping and integrating transcriptional and epigenetic profiling specific to RE families. The main goals of the project are: i) to uncover key molecular determinants involved in RE expression; ii) to validate the role of specific transcriptional and epigenetic modifiers in RE regulation; iii) to define the biological significance of RE modulation using state‑of‑the‑art in vitro models and innovative bioinformatic analysis frameworks. The project focuses on small‑cell lung cancer (SCLC), which is characterized by a prominent neuroendocrine phenotype.