I have been working at ITB since 2021, focusing on clinical proteomics using LC–MS to investigate molecular mechanisms of diseases, particularly cancer and neurodegenerative disorders. My work spans the full proteomics workflow, including preparation of biological samples, operation of LC-MS platforms, and omics data analysis using bottom‑up, untargeted, label‑free approaches with DDA and DIA acquisition. I analyze samples such as cell lines, tissues, and biofluids using trap‑and‑elute nanoLC systems coupled to high‑resolution TOF and Orbitrap mass spectrometers. I use specialized software for protein identification, quantification, and statistical and systems biology analyses. My research aims to identify molecular differences between conditions for subject stratification, pathway analysis, and biomarker discovery. I also optimize LC–MS and computational methodologies and contribute to laboratory instrument management and maintenance. I collaborate with different national (IRCCS) and international (Japan) research groups. I am part of the proteomics community in the Elixir infrastructure.
Research Activities
Sample preparation (cell lines, tissues, organs, biofluids, extracellular vesicles).
Proteomic analysis integrating high-resolution and high-speed mass spectrometers with micro- and/or nano-fluidic chromatography systems
Computational analysis and pipeline development for qualitative and quantitative proteome characterization, including network analysis within a systems biology approach.
Management and maintenance of LC-MS platforms, including cleaning, calibration, diagnostics, and repair
