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Proteomics

Here at the Institute for Biomedical Technologies, a specialized team of researchers is dedicated to proteomics research, combining advanced experimental and computational expertise to investigate protein composition, dynamics, and function in complex biological systems. The group covers the full proteomics workflow, from sample preparation across diverse biological matrices to high-resolution LC–MS–based analyses using state-of-the-art mass spectrometry and micro-/nano-fluidic chromatography platforms. In parallel, the team develops and applies computational pipelines for qualitative and quantitative proteome characterization, integrating network and systems biology approaches. Strong technical expertise in the management, optimization, and high-throughput development of LC–MS platforms supports robust and reproducible analyses. These activities underpin biomarker discovery and validation for precision medicine applications and are complemented by research services for academia and industry, promoting technology transfer, training, and open-access proteomics.

Research Activities

Sample preparation (cell lines, tissues, organs, biofluids, extracellular vesicles).

Proteomic analysis integrating high-resolution and high-speed mass spectrometers with micro- and/or nano-fluidic chromatography systems

Computational analysis and pipeline development for qualitative and quantitative proteome characterization, including network analysis within a systems biology approach.

Management and maintenance of LC-MS platforms, including cleaning, calibration, diagnostics, and repair

Development and Optimization of High-Throughput LC‑MS Pipelines for Proteomics Research

Biomarker discovery and validation through LC‑MS–based proteomics for early diagnosis, prognosis, therapy monitoring and patient stratification in precision medicine.

Research services with advanced proteomics technologies for academia and industry, fostering technology transfer, training and open access practices