I have been a researcher at ITB-CNR since 2006 and currently coordinate the Computational Clinical Proteomics group.
Over the past 15 years, my research has focused on omics sciences, particularly proteomics, and systems biology, using graph theory and network models that include protein-protein interactions, co-expression, signaling, and miRNA targeting. These approaches have been applied across the board in the biomedical field and in the study of viruses, microorganisms, and plants. Specifically, they have been used to understand the molecular mechanisms underlying various diseases and to monitor their therapeutic efficacy. In this context, cardiovascular, amyloid, lung, and cancer diseases are among the most frequently addressed topics. Equally significant is the number of studies focused on understanding the immune system.
My research and development activities have been carried out in parallel with visiting periods at international public and private research institutions, including the Center for Complex Network Research (CCNR) at Northeastern University (Boston, USA), EMBL-EBI (Cambridge, UK), Scripps Research Institute (San Diego, USA), and North Carolina State University (Kannapolis, USA).
Research Activities
Proteomic analysis integrating high-resolution and high-speed mass spectrometers with micro- and/or nano-fluidic chromatography systems
Computational analysis and pipeline development for qualitative and quantitative proteome characterization, including network analysis within a systems biology approach.
Development of innovative methodologies in network medicine, leveraging molecular networks and pathways for integrative data analysis
Multiomic integration to identify regulatory pathways, gene modules, protein networks, and composite signals associated with pathological phenotypes.
Development of human interactome models and null models for network-based analysis.
