Roberta Alfieri

I am a bioinformatician at the CNR ITB in Segrate (Milan). My research focuses on the analysis and integration of high-throughput sequencing data — including bulk and single-cell RNA-seq, spatial transcriptomics, long-read sequencing — to investigate the molecular mechanisms underlying cancer, rare genetic diseases, immune and neurological-related disorders. My career at CNR began in 2006 at ITB, then continued at the National Institute of Molecular Genetics (INGM) from 2015 to 2017. From 2018 to 2022, I worked as a technologist at the Institute of Molecular Genetics (IGM) of the CNR, before returning to ITB, where I am currently based. I have extensive experience in transcriptomic data analysis and in the development of bioinformatics pipelines for complex datasets. My recent work includes studies on the tumor microenvironment in lung cancer, the molecular basis of visceral myopathies, transcriptional signatures in leukodystrophies, and the characterization of mechanisms of hematopoietic clonal dominance in VEXAS syndrome. I actively collaborate with several national and international partners, including TIGET–San Raffaele, the University of Florence, CNRS Valbonne, the University of Lisbon, CNR-IBF, and CNR-IGM. My research has contributed to peer-reviewed publications in leading journals such as Nature Medicine, RNA, and Cancer Research Communications.