Research Activities
Development and validation of patient-specific 3D models, based on iPSCs, to investigate the molecular and epigenetic mechanisms during the onset and progression of cardiovascular and skeletal muscle diseases
Establishment of advanced 3D cultures and organoid-based systems that faithfully recapitulate tissue architecture and microenvironmental complexity for in vitro modelling of human diseases
Design of next-generation regenerative strategies integrating stem cells, functional biomaterials and 3D modelling to restore structure and function in damaged cardiac and skeletal muscle tissues
Engineering of vascularized and functional tissue constructs for translational and preclinical applications, with the aim of accelerating the transfer of regenerative technologies toward clinical use
Investigation of dynamic cell–cell and cell–matrix communication , with a focus on extracellular vesicles and biomechanical cues regulating tissue regeneration and disease progression
Harnessing extracellular vesicle–mediated signaling to actively modulate regeneration, immune interactions and pathological remodeling within engineered 3D tissue models
