Cellular and Tissue Biomedicine
RESEARCH AREA
research line
Reprogramming, Stem cells and advanced 3D Modelling
This research line focuses on leveraging stem cells, reprogramming differentiated cells to induced Pluripotent Stem Cells (iPSCs), and Advanced 3D systems to model human diseases and develop patient-derived, physiologically relevant in vitro models. By generating patient‑specific models, including tumor, brain, cardiovascular, and muscle systems, it enables detailed investigation of disease mechanisms, cellular heterogeneity, and microenvironmental interactions within highly physiologic experimental platforms.
Research Activities
Study of molecular and cellular mechanisms in tumorigenesis with a focus on dissecting cellular heterogeneity and interactions within the tumor microenvironment
Development of 3D patient-derived organoids recapitulating in vitro disease models to study the interactions between host and components of surrounding microenvironment
Study of neurodevelopmental disorders physiopathology through the generation of patients iPSCs-derived brain organoids as model systems
Development and validation of patient-specific 3D models, based on iPSCs, to investigate the molecular and epigenetic mechanisms during the onset and progression of cardiovascular and skeletal muscle diseases
Establishment of advanced 3D cultures and organoid-based systems that faithfully recapitulate tissue architecture and microenvironmental complexity for in vitro modelling of human diseases
