I am a researcher at ITB-CNR with a extensive experience in molecular oncology and stem cell research since 2009. My work focuses on developing advanced in vitro and ex vivo models to accelerate translational research and unravel cancer biology. I investigate the molecular and cellular mechanisms driving tumor development and heterogeneity using cellular, molecular, and bioinformatics approaches. My research includes gene function studies in stem cells and cancer via gene expression modulation, 3D organoid cultures from primary tissues to model diseases in vitro; CRISPR-based screening platforms for gene therapy; and the study of microbiota-host interactions in ex vivo models. I’m author/co-authors of several scientific publications on peer-reviewed international journals, and collaborate with national, international and clinical institutes.
Research Activities
Characterization of the functional landscape of single nucleotide variants (SNV) in disease models by using large-scale CRISPR screens and quantifying variant effects via phenotypic and transcriptional readouts
Study of the microbiota-host-exposome interactions to elucidate how microbial dynamics and metabolite profiles influence host physiology and disease mechanisms
Determination of how Single Nucleotide Variants (SNVs) in RNA-modification effectors influence cancer cell proliferation and drug resistance
